Gain-of-function on the hot seat

From: POLITICO Future Pulse - Wednesday Sep 13,2023 06:02 pm
Presented by Arnold Ventures: The ideas and innovators shaping health care
Sep 13, 2023 View in browser
 
Future Pulse

By Carmen Paun, Erin Schumaker and Daniel Payne

Presented by Arnold Ventures

WASHINGTON WATCH

WUHAN, CHINA - JULY 18: (CHINA OUT)The bat specimen on display at the "Enlightenment Of COVID-19" science exhibition on July 18, 2021 in Wuhan, Hubei Province, China. The exhibition aims to explain the unique life form of the coronavirus and the thinking behind China's fight against the pandemic, as well as exploring ways to achieve a long-term coexistence with the virus. With no recorded cases of COVID-19 community transmissions since May 2020, life for residents in Wuhan is gradually returning to normal. (Photo by Getty Images)

Researchers have long seen bat viruses as particularly dangerous. | Getty Images

The Biden administration is getting more squeamish about funding virus studies, amid a GOP-led House investigation into Covid’s origins and Republican efforts in Congress to scale back virus research.

The latest sign of administration reconsideration came last week when the U.S. Agency for International Development halted funding for a Washington State University program seeking to identify animal viruses that might cause a pandemic.

The decision, first reported by the British Medical Journal, came after Jim Risch of Idaho, the highest-ranking Republican on the Senate Foreign Relations Committee, criticized it and said he feared the risks outweighed potential benefits.

A spokesperson for USAID, to whom POLITICO granted anonymity because the official was not authorized to speak on the record, said the move was part of a larger rethink of virus research.

“The Covid-19 pandemic has led USAID and the U.S. government as a whole to assess priorities and approach to pandemic preparedness,” the spokesperson said.

On the Hill: Republicans are targeting must-pass legislation to codify virus research restrictions.

A House Appropriations subcommittee approved a draft fiscal 2024 funding bill for the Department of Health and Human Services in July that prohibits federal funding for so-called gain-of-function research, which seeks to make viruses more virulent or transmissible or both to help study them.

Meanwhile, Sen. Joni Ernst (R-Iowa) succeeded in June in convincing fellow members of the Armed Services Committee to amend the annual defense policy bill to bar the Pentagon from funding either the EcoHealth Alliance, a research group that has collaborated with China’s Wuhan Institute of Virology on virus research, or the institute itself.

That collaboration is at the center of the theory that the coronavirus was the result of a lab accident in Wuhan, the city where Covid-19 first emerged.

The Biden administration in May restored funding for EcoHealth, but has barred any further work with the Wuhan institute.

 

A message from Arnold Ventures:

Same service, same price. You should be charged the same price when you receive the same medical service, no matter where you get it. But today, patients, employers, and taxpayers are charged billions because big hospital systems are buying up small physician practices. And when the logo on the door changes, you pay over 14% more for the same routine services. It's time to make site-neutral health care a reality. Learn more.

 
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This is where we explore the ideas and innovators shaping health care.

Many Americans committed to staying up to date on their Covid boosters will get their sixth shots this month, if they achieved full vaccination with either Moderna or Pfizer/BioNTech’s two-shot regimens.

But most Americans aren’t convinced of the need: The most vaccinated state is Massachusetts, where the average resident has gotten 2.6 jabs, according to the Centers for Disease Control and Prevention. In 28 states, the average is under 2.

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WORLD VIEW

New tools should make it easier to bring down maternal mortality.

New tools should make it easier to bring down maternal mortality. | AP Photo/Rajesh Kumar Singh

A new mother died every two minutes somewhere in the world in 2020, the latest year for which the World Health Organization has data.

And while understanding of the causes of their deaths has greatly improved, innovations that could save women’s lives aren’t reaching many of those who live in low- and middle-income countries.

Even in the U.S., where the death rate for new Black mothers has doubled since 1999, many aren’t benefiting from maternal mortality advancements, according to the Bill & Melinda Gates Foundation.

“Giving birth is the oldest medical challenge that the human race has faced,” foundation CEO Mark Suzman told Carmen. “If it was seen as a higher political priority, and resource priority, it’s quite clear, at minimum, the U.S. should be able to have outcomes in line with those of other high-income countries,” he said.

The foundation’s 2023 Goalkeepers report highlights innovations that could save new mothers’ lives:

1. Interventions that reduce bleeding after childbirth, the top cause of maternal death.

2. Multiple micronutrient supplements to replete pregnant women’s nutrient stores.

3. A one-time IV iron therapy to replenish women’s reserves during pregnancy. This protects against and also treats anemia, a condition that’s both a cause and effect of postpartum hemorrhage and affects almost 37 percent of pregnant women.

4. Antenatal corticosteroids, given to women at high risk of giving birth prematurely. The drug helps to accelerate a baby’s lung development.

5. Azithromycin, an antibiotic that reduces maternal infections during pregnancy and prevents sepsis, which causes 23 percent of maternal deaths in the U.S.

6. An AI-enabled portable ultrasound for nurses and midwives to monitor high-risk pregnancies in low-resource settings to ensure that risks are diagnosed and addressed early.

 

A message from Arnold Ventures:

When hospitals consolidate, prices go up, and everyone loses. As big hospitals are gaming the system, patients and taxpayers are paying the price. Site-neutral payment policies would put an end to hospital consolidation, and protect Americans from more than $140 billion in overpayments every year. It’s no wonder that 85% of voters from both sides support site-neutral policy solutions. Now, Congress has the opportunity to protect patients and save taxpayer dollars. It’s time to put patients before profits and enact site-neutral health care. Learn more.

 
 

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THE NEXT CURES

IN SPACE - FEBRUARY 18: In this photo provided by the European Space Agency (ESA) and NASA, the International Space Station is seen from Atlantis as the orbiter undocks February 18, 2008 in space. Atlantis delivered the long awaited, $2 billion Columbus science lab addition built by the ESA to the space station. (Photo by ESA/NASA via Getty Images)

NASA will now conduct cancer research aboard the International Space Station. | Getty Images

Cancer research in space, diversified clinical trials and more virtual care are among the new initiatives the Biden administration will unveil at a meeting of the White House’s “Cancer Cabinet” today.

It’s all part of achieving President Joe Biden’s goal of reducing the cancer death rate by half over the next 25 years.

Among the most noteworthy plans:

— $240 million for ARPA-H 

The Advanced Research Projects Agency for Health will fund efforts to prevent, detect and treat cancer, such as tools to detect the disease early.

— A biomedical data toolbox

ARPA-H, the National Institutes of Health, and the National Cancer Institute will integrate their cancer datasets to make them more helpful to researchers.

— A campaign to diversify clinical trials

A new nationwide network, ARPANET-H, will bring clinical trials to underserved communities.

— Smoking cessation resources 

A $15 million program will seek to reduce menthol and flavored tobacco use. Another drive aims to bring down smoking rates among underserved groups, including American Indian, Alaska Native and Black communities.

— Cancer research in space

NASA’s Division for Biological and Physical Sciences will fund studies of the disease on the International Space Station.

— Expanding virtual cancer care for veterans

The Department of Veterans Affairs is adding 30-plus sites to its national virtual care oncology program.

 

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